Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are long-chain polyunsaturated omega-3 fatty acids derived from marine sources, such as oily fish and fish oil or algal products. EPA and DHA act in the body via cell membrane incorporation, specific cellular receptors, and the generation of critical down-stream lipid mediators such as eicosanoids and specialized pro-resolving mediators (SPMs). The EPA & DHA Research Review covers the sources, recommendations, functions, and various areas of clinical support for EPA and DHA, including cardiovascular, cognitive, eye, child and maternal health.