The Nutrition Masters Course on The Endocannabinoid System (ECS) explores the ECS, a critical homeostatic regulator in the body. Topics include ECS research history, ECS-related compounds and terminology, diverse physiological functions of the ECS, endocannabinoid tone, clinical endocannabinoid deficiency (CED), and potential clinical strategies to support ECS function—including phytocannabinoid bioactives found in the Cannabis plant (e.g., from hemp extract).