In this interview, Robert Martindale, MD, PhD, sheds light on the benefits of immunonutrition and SPMs in patient recovery post-surgery. He highlights how these nutritional strategies help modulate the immune response and improve outcomes for surgical and critical care patients. Dr. Martindale addresses the challenges of integrating such approaches into patient care. He also explores how nutritional interventions can influence metabolic balance and accelerate recovery, expressing enthusiasm for ongoing research in this field. Robert Martindale, MD, PhD, is a Professor…
In this interview, Robert Martindale, MD, PhD, sheds light on the benefits of immunonutrition and SPMs in patient recovery post-surgery. He highlights how these nutritional strategies help modulate the immune response and improve…
In this interview, Michael Conte, MD, delves into the role of SPMs in treating vascular diseases. He highlights the potential of synthetic resolvin D1 analogues to improve the management of vascular injuries and control post-surgical inflammation. Dr. Conte also emphasizes the importance of future research on SPMs, particularly in enhancing surgical recovery and developing biomarkers to optimize treatment strategies before and after surgery. Michael Conte, MD, is the Chief and Professor of Vascular Surgery at the University of California, San…
In this interview, Michael Conte, MD, delves into the role of SPMs in treating vascular diseases. He highlights the potential of synthetic resolvin D1 analogues to improve the management of vascular injuries and…
In this interview, Krishnarao Maddipati, PhD, discusses his research in metabolipidomics, focusing on the role of SPMs in cellular processes he calls "unalamation”. He highlights significant findings, including how dietary supplementation can boost SPM production, leading to innovative therapeutic strategies for managing diseases by harnessing the body's natural resolution mechanisms. Krishnarao Rao Maddipati, PhD, is a Professor and Director of Lipidomics Core Facility at Wayne State University
In this interview, Krishnarao Maddipati, PhD, discusses his research in metabolipidomics, focusing on the role of SPMs in cellular processes he calls "unalamation”. He highlights significant findings, including how dietary supplementation can boost…
In this interview, Janos Filep, MD, PhD, discusses the role of aspirin-triggered resolvins and lipoxins in infection control, especially in sepsis. Dr. Filep is exploring how these molecules can restore immune function in patients with compromised phagocytosis. He also investigates the interaction between IFN-β and these mediators in clearing lung infections and outlines the challenges in developing therapies based on aspirin-triggered SPMs for infectious diseases. Janos Filep, MD, PhD, is a Professor of Pathology and Cell Biology at the University…
In this interview, Janos Filep, MD, PhD, discusses the role of aspirin-triggered resolvins and lipoxins in infection control, especially in sepsis. Dr. Filep is exploring how these molecules can restore immune function in…
In this interview, Gabrielle Fredman, PhD delves into the role of SPMs, particularly resolvin D2, in the resolution of chronic inflammation in cardiovascular conditions such as atherosclerosis. She discusses how RvD2 facilitates the resolution of inflammation and the reduction of plaque formation, focusing on how it corrects imbalances in lipid mediators that fuel atherosclerosis. Looking ahead, Dr. Fredman's research will concentrate on understanding the mechanisms that may become dysregulated with aging, and how Resolvins could contribute to organ protection as…
In this interview, Gabrielle Fredman, PhD delves into the role of SPMs, particularly resolvin D2, in the resolution of chronic inflammation in cardiovascular conditions such as atherosclerosis. She discusses how RvD2 facilitates the…
In this interview, Bruce Levy, MD discusses the scientific basis of SPMs in respiratory health, emphasizing their role in lung inflammation resolution, particularly for asthma and RSV infections. He notes the impact of lipoxin deficiency on asthma severity and how supplementation with these mediators offers therapeutic potential, promoting tissue repair and reducing lung damage. Dr. Levy stresses the importance of dietary strategies in enhancing SPM functionality and overall respiratory health, underscoring the need for innovative therapeutic approaches to address severe…
In this interview, Bruce Levy, MD discusses the scientific basis of SPMs in respiratory health, emphasizing their role in lung inflammation resolution, particularly for asthma and RSV infections. He notes the impact of…
In this interview, Alpdogan Kantarci, DDS, PhD, discusses the impact of SPMs on periodontal health and systemic inflammation. He reviews his research on SPMs and their role in linking oral inflammation to Alzheimer's disease, emphasizing their therapeutic potential. Dr. Kantarci also highlights the importance of nutrition in managing these conditions. Looking ahead, he discusses his plans for future research aimed at translating these findings into clinical practice, with the potential to improve treatment strategies for both oral and neurodegenerative diseases.…
In this interview, Alpdogan Kantarci, DDS, PhD, discusses the impact of SPMs on periodontal health and systemic inflammation. He reviews his research on SPMs and their role in linking oral inflammation to Alzheimer's…
Most patients seeking pain relief rely on the following three families of drugs: opioids, gabapentinoids, and nonsteroidal anti-inflammatory agents (NSAIDs). These widely used drugs are associated with serious side effects.1 During the past decade there has been an increasing interest in cannabis-derived natural products for pain management with a better safety profile and adequate pain relief. However, we still know surprisingly little about the effectiveness on pain of nonintoxicating cannabis-based products—conventionally referred to as “industrial hemp.” To fill this knowledge…
Most patients seeking pain relief rely on the following three families of drugs: opioids, gabapentinoids, and nonsteroidal anti-inflammatory agents (NSAIDs). These widely used drugs are associated with serious side effects.1 During the past…
by Michael Stanclift, ND Many of us have been using omega-3 fats, such as fish oil, for managing inflammatory conditions. Interestingly, fish oil and special molecules made from them called specialized pro-resolving mediators (SPMs) have big impacts on our immune system and play an important role in the activity of immune cells. The key lies in how fats such as the ones found in fish oil influence the behavior of the white blood cells (WBCs) of our immune system. Our…
by Michael Stanclift, ND Many of us have been using omega-3 fats, such as fish oil, for managing inflammatory conditions. Interestingly, fish oil and special molecules made from them called specialized pro-resolving mediators…
In this interview, Dipak Panigrahy, MD discusses the emerging impact of specialized pro-resolving mediators (SPMs) on tumor size and growth, highlighting his work with several preclinical models including pancreatic cancer and breast cancer. Dr. Panigrahy outlines the reduction in metastases seen in preclinical cancer models, including pancreatic cancer, following treatments with various SPMs. Finally, Dr Panigrahy describes results in preclinical models showing that SPM treatment helps to clear tumor debris caused by standard of care cancer treatments. Dipak Panigrahy, MD,…
In this interview, Dipak Panigrahy, MD discusses the emerging impact of specialized pro-resolving mediators (SPMs) on tumor size and growth, highlighting his work with several preclinical models including pancreatic cancer and breast cancer.…
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