In this interview, Professor Charles Serhan, PhD, DSc describes new work highlighting the connection between specialized pro-resolving mediators (SPMs) and the vagus nerve. Dr. Serhan reflects back at his proudest moments of his career, and on the most exciting recent developments. Finally, Dr. Serhan delivers a message on the state of resolution science today, and what is needed to advance SPM-based therapies in the future. Charles Serhan, PhD, DSc is Director of the Center for Experimental Therapeutics and Reperfusion Injury…

As part of this conversation, Gabrielle Fredman, PhD describes what is meant by the failure of resolution, and the mechanisms that can drive this failure in atherosclerosis. Dr. Fredman ends by outlining the potential for specialized pro-resolving mediator (SPM) therapies in the management of vascular disease. Gabrielle Fredman, PhD is Associate Professor at Albany Medical College, Department of Molecular and Cellular Physiology. From the 16th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, October 2019 in St…

In this Grand Rounds presentation, Niccolò Terrando, PhD shares scientific research on the role of specialized pro-resolving mediators (SPMs) in perioperative neurocognitive disorders. Dr. Terrando uses a preclinical mouse model to study postoperative neuroinflammation and elucidate the impact of SPMs in neuroglia activity and modulating memory.

by Kari Hamrick, PhD, RD and Elnaz Karimian-Azari, PhD Introduction Since 2016, the US Department of Health and Human Services has brought a new level of awareness to the opioid crisis in America by declaring it a nationwide Public Health Emergency.1 In the US, it is approximated that 2.5 million people have been diagnosed with an opioid use disorder (OUD), and 4 in 5 new heroin users started out misusing opioid prescription pain medication.2 As part of the efforts aimed…

Terry Wahls, MD challenges the conventional medical view that MS is progressive and degenerative and shares her personal journey with MS, which is a shining example that healing is possible. This riveting story reveals how a once-conservative academic internal medicine doctor came into direct conflict with the very material she was meant to teach her med students and had to find new answers to medically “unsolvable” problems.

by Erik Lundquist, MD Metagenics Institute sat down with family physician Erik Lundquist, MD for a Q&A session to bust some myths about the Cannabis plant and glean current insights for our readers on the clinical utility of phytocannabinoids naturally found in Cannabis, like cannabidiol (CBD). Read on to learn how, based on the scientific literature and in Dr. Lundquist’s clinical experience, these unique bioactives with actions in the endocannabinoid system (ECS) may be relevant to you and your patients.…

Host: Deanna Minich, PhD Guest: Erik Lundquist, MD In this discussion, Erik Lundquist, MD and Deanna Minich, PhD explore thyroid physiology, assessment, and clinical pearls for treating patients with thyroid dysfunction or disorders. The crux of the discussion is treating the individual patient, not the labs. You will learn valuable insights and effective clinical strategies that Dr. Lundquist utilizes every day in his clinic to provide personalized support to patients with thyroid disorders. Dr. Lundquist shares that in his medical school…

by Sara Gottfried, MD and Melissa Blake, BSc, ND Hormones drive the many functions of our body and mind. For example, hormones and their receptors influence metabolic function, heart rate, appetite, tissue growth, and development. Ultimately, the body relies on the hormonal signals of a strikingly choreographed endocrine system. Most of the endocrine system is regulated by the hypothalamic-pituitary-adrenal-thyroid-gonadal (HPATG) axis, which is instrumental in regulating mood, reproductive health, and general homeostasis.1 Unfortunately, the HPATG axis is remarkably sensitive to…

by Sara Gottfried, MD; Annalouise O’Connor, PhD, RD; Lewis Chang, PhD If we go back a few decades, scientists and clinicians considered the leading public health killers—such as heart disease, cancer, Alzheimer’s disease, diabetes—to be separate diseases. Now we know they have a common root cause: inflammation, the process by which the body’s white blood cells are recruited and activated for a specific purpose. Acute inflammation is triggered to help fight an infection or illness, or to heal an injury,…

Host: Deanna Minich, PhD Guest: Kara Fitzgerald, ND In this discussion, Kara Fitzgerald, ND and Deanna Minich, PhD explore the active process of inflammation resolution and how to provide clinical support to quench inflammation chronicity in your patients. Dr. Fitzgerald thinks of inflammation broadly, as a complex immune response to a variety of inputs. The offensive input could be a pathogenic insult like a bacterial or viral infection, and the inflammatory response is acute and protective to the patient. But when…