Search Results for: Probiotic

Results from a recent small randomized clinical trial found that a combined probiotic and peanut oral immunotherapy (PPOIT) may potentially be an effective option to manage children with peanut allergy and the treatment effect may last for at least 4 years.1Previously, researchers at the Murdoch Children’s Research Institute (Melbourne, Australia) conducted a randomized, double-blind, placebo-controlled trial to investigate the effect of PPOIT in 62 children with peanut allergy. For 18 months, children received either placebo or PPOIT (2 x 1010 CFU of Lactobacillus…

Results from a supplementation trial demonstrated that the combination of probiotics and omega-3 fatty acids reduced the risk for steatosis (fatty liver) in patients with nonalcoholic fatty liver disease (NAFLD)1. Previous research has shown that modulation of the gut microbiota via probiotics supplementation may have beneficial effects on the gut-liver axis and metabolic and immunologic responses, and omega-3 supplementation may improve liver lipid metabolism and adipose tissue function. 2,3 Seeing the potential, researchers from the Bogomolets National Medical University (Kiev, Ukraine)…

In this presentation Gail Cresci, PhD, RD reviews how digestive health is enhanced when the gut microbiome is rich in diverse micro flora. This diversity is supported when preferred energy sources for the bacteria are available and support the viability of microbiota. The importance of these combinations lies in the fact that a metabolic environment is created which in turns provides protection of the gut barrier, optimal immune response and normal gut function and influences on a variety of other…

Probiotics Video Animation This animation is designed for the educational use of clinicians and patients. The human gut is home to over 100 trillion bacterial cells, known as the gut microbiota. The bacteria are diverse and contain mostly “good” bacteria that help process the foods we consume and produce vitamins and short-chain fatty acids that help our bodies to function. The gut bacteria also produce metabolites that communicate with the brain and the rest of the body. They may influence…

Small intestinal bacterial overgrowth (SIBO) is a disorder characterized by an excessive concentration of bacteria in the small intestine (exceeding 105 organisms/mL). Patients with SIBO commonly report abdominal pain, flatulence, bloating, and diarrhea, and may experience malabsorption and weight loss in more severe cases.1 The standard regimen to manage SIBO has been antibiotic therapy, but this may disrupt the normal balance of the gut microbiota and can increases the risk of developing antibiotic resistance. Further, the antibiotics used are often bacteriostatic, not…

Over the past decade, increasing evidence has linked the intestinal microbiome with regulation of body weight and body fat mass. Preclinical research on the probiotic strain Bifidobacterium animalis ssp. lactis 420 (B420) demonstrates improved intestinal barrier function, satiety signaling, body weight, and body fat regulation. A 6-month clinical study in obese men and women demonstrated that B420 helped control body fat and weight, as well as reduced energy intake and promoted short-chain fatty acid production. Download the PDF: Probiotic 420 and…

This presentation, entitled, “Probiotics: From Basic Science to Clinical Application” was delivered by Eamon M Quigley, MD at the ASPEN Symposium in February 2015. Dr. Quigley is the Chief of the Division of Gastroenterology and Hepatology at Houston Methodist Hospital in Texas. His presentation begins with a definition of probiotics and discussion of the health benefits they can have on the body. Current clinical applications for probiotics include diarrheal illnesses, necrotizing enterocolitis, inflammatory bowel disease, irritable bowel syndrome, and liver…

By: Yekta Dowlati, PhD Maintaining gut homeostasis is foundational to overall health, with increasing research emphasizing the gut microbiota’s pivotal role in immunity, digestion, and systemic well-being. Modern lifestyle factors such as poor diet, antibiotic exposure, infections, and aging can disrupt this microbial balance, creating opportunities for health deterioration. Probiotics are defined by the International Scientific Association for Probiotics and Prebiotics (ISAPP) as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host.”1 In contrast,…

by Kyle Perkovich, BS The gut, often referred to as the body’s “second brain,” is central to overall health, influencing everything from digestion to immune function, metabolism, and even mental health.1-3 Emerging research consistently demonstrates that a balanced and diverse gut microbiome is essential for overall health and a key aspect of every patient’s wellness. The gut microbiome – a complex ecosystem containing trillions of bacteria and other microorganisms – helps regulate digestion and communicates with various body systems through neurotransmitters,…

by Yekta Dowlati, PhD According to the World Health Organization (WHO), approximately 2 billion adults globally are overweight, with 650 million classified as obese. Projections suggest that, if current trends persist, the number of overweight adults could reach 2.7 billion by 2025, with the obese population surpassing 1 billion.1,2 Obesity, a complex condition, emerges from an interplay of genetic, societal, and environmental factors and induces metabolic alterations, including changes in gut microbiota, systemic inflammation, and intestinal barrier dysfunction.3,4 Approximately 31%…