In this interview, Matthew Spite, PhD discusses his research on the intersection of inflammation resolution via specialized pro-resolving mediators (SPMs) and tissue repair.  He explains how their animal models demonstrate the ability of SPMs to promote tissue vascularization in cases of tissue injury or ischemia. Additionally, Dr. Spite elaborates on how Maresins can not only resolve inflammation but might also mitigate obesity, thus improving systematic metabolism. He is then asked to delve into his work concerning the role of Maresins…

In this interview, Catherine Godson, PhD discusses the protective role of lipoxins against inflammation in diabetes associated atherosclerosis. She offers insights into the future direction of research focused on inflammation resolution. Dr. Godson emphasizes the necessity for treatments targeting chronic complications of diabetes, which promotes resolution on top of standard care therapies. She also elaborates on her research involving lipoxins in the context of chronic complications of disease and inflammation. Catherine Godson, PhD, is a Professor of Molecular Medicine and…

In this interview, Jesmond Dalli, PhD, focuses on effective therapeutic approaches for resolving joint inflammation and regeneration, while highlighting the shortcomings of some existing treatments. He details his latest research on the use of Maresins in treating rheumatoid arthritis patients and the clinical insights gained from this work. Dr. Dalli concludes by explaining how specialized pro-resolving mediators (SPMs) offer a novel approach to therapy and can complement standard pain management treatments. Jesmond Dalli, PhD, is a Professor of Molecular Pharmacology…

In this interview, Bruce Levy, MD discusses the most interesting research over the last few years, such as the development of mRNA vaccines, growth in cell-based therapies and expansion of interest in resolution biology. Dr. Levy describes the potential link between long COVID and dysregulation of resolution mediators and mechanisms. He further describes cytokine storm in this context. Dr. Levy also discusses the significance of external use of specialized pro-resolving mediators (SPMs) in resolving inflammation in some of the chronic…

In this interview, Gabrielle Fredman, PhD delves into the role of SPMs in aging. She elaborates on the research and potential of using specialized pro-resolving mediators (SPMs) endogenously as a preventative measure against aging. Additionally, Dr. Fredman discusses various internal factors involved in the resolution of inflammation and the mechanisms that might impede this process. She concludes by sharing her research findings on the connection of SPMs and atherosclerosis. Gabrielle Fredman, PhD, is an Associate Professor of Molecular and Cellular…

In this interview, Edward Botchwey, PhD delves into the use of emerging technologies like metabolomics to identify insufficiencies in endogenous lipid mediators that may impact tissue healing. Dr. Botchwey outlines his research on synergizing bioengineering with traditional rehabilitation medicine, with the goal of delivering immunomodulatory compounds such as specialized pro-resolving mediators (SPMs) directly to the injured tissue to achieve satisfactory wound healing. Edward Botchwey, PhD, is a Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech…

In this interview, Dipak Panigraphy, MD discusses cytokine storms in both COVID-19 and cancer patients, emphasizing their potential to disrupt resolution of inflammation and contribute to unfavorable clinical outcomes. Dr. Panigraphy discusses how standard cancer treatments, including surgery and chemotherapy, may trigger cytokine storms, facilitating the spread of cancer in some patients. Lastly, he discusses his latest research, demonstrating the efficacy of specific specialized pro-resolving mediators (SPMs) molecules in promoting inflammation resolution and preventing treatment-induced metastasis in multiple preclinical cancer…

Akkermansia muciniphila is a unique mucin-loving keystone species residing in the human gastrointestinal tract, purportedly offering health benefits, especially in the realms of metabolic health and obesity.1 Clinical investigations exploring A. muciniphila supplementation in overweight and obese cohorts seek to elucidate its potential impact on metabolic parameters, adiposity, and other health metrics. Studies consistently show reduced abundance in obesity, type 2 diabetes, high blood pressure, and other metabolic conditions.2 Intervention studies in animals demonstrated A. muciniphila administration reversed high-fat diet-induced metabolic disorders,…

by Kyle Perkovich, BS In the intricate ecosystem of the human gut, a new frontier is emerging, marked by the strategic paring of probiotics and prebiotics working synergistically to help provide optimal gut health and well-being. This combination, known as synbiotics, is gaining prominence for its potential to enhance gut health and immune function. As research has advanced, the role of our gut microbiota has become increasingly recognized as a vital part of overall health, influencing not only proper digestion,…

by Lewis Chang, PhD Not all heroes are muscle-bound and wear capes. There is a tiny, almost invisible, hero that lives in our gut and promotes our health and wellbeing. Its name, Akkermansia muciniphila, may be a mouthful, but it’s time to get to know this hero better, as its health-promoting effects have earned it the reputation as a next-generation beneficial bacteria.1 Gut health is intricately connected to human health in ways that surprise us. Our gut is home to…